Find us on:


Low-dose naltrexone, an opioid-receptor antagonist, is a broad-spectrum analgesic: a retrospective cohort study

Low-dose naltrexone, an opioid-receptor antagonist, is a broad-spectrum analgesic: a retrospective cohort study
Publication Type
Journal Article
Research Type
Reported as
Case Report/Series/Restrospective Study
March 15, 2022
Samuel J Martin, Heath B McAnally, Paul Okediji, Moshe Rogosnitzky
MedInsight Research Institute, University of Washington School of Medicine, Loma Linda University School of Medicine, Northern Anesthesia & Pain Medicine

Naltrexone has historically been used to treat various substance use disorders, but recent discoveries have sparked interest in using low-dose naltrexone (LDN) to manage chronic pain. This study compared pain levels reported by patients before and after at least 2 months of LDN treatment to those reported by patients with the same painful diseases, who did not take LDN. Overall, patients who took LDN reported significantly more pain relief than patients who did not take LDN. How LDN alleviates pain seems complex, but apparently involves an anti-inflammatory effect on cells in the brain and spinal cord. LDN is extraordinarily safe, with no known risks (unlike most standard pain medications), and should be studied more in the treatment of chronic pain.

AIM: To evaluate the use of low-dose naltrexone (LDN) as a broad-spectrum analgesic.

METHODS: Retrospective cohort study from a single pain management practice using data from 2014 to 2020. Thirty-six patients using LDN for ≥2 months were matched to 42 controls. Pain scores were assessed at initial visit and at most recent/final documented visit using a 10-point scale.

RESULTS: Cases reported significantly greater pain reduction (-37.8%) than controls (-4.3%; p < 0.001). Whole sample multivariate modeling predicts 33% pain reduction with LDN, with number needed to treat (for 50% pain reduction) of 3.2. Patients with neuropathic pain appeared to benefit even more than those with ‘nociceptive’/inflammatory pain.

CONCLUSION: LDN is effective in a variety of chronic pain states, likely mediated by TLR-4 antagonism.

vape no A Tag

fda approved cbd oil cbd oil near charlotte nc buy cbd oil near me cbd oil international regulations cbd nausea does cbd show on drug test free cbd trial be know do cbd oil constipation cbd flower indiana free cbd oil samples free shipping charlottes web cbd retailers rick simpson cbd oil cbd powder wholesale cbd pure hemp oil 600 reviews does cbd oil raise blood sugar cbd oil and vertigo cbd oil erectile dysfunction reddit how to dilute cbd oil will cbd oil cause a positive drug test cbd oil for non epileptic seizures cbd oil order online jgo cbd review spectrum cpm gronkowski cbd oil dangers of cbd cbd oil for anxiety near me health shops gastonia nc cbd oil cbd extraction lab pizza sydney cbd cbd laws tn cbd releaf can you drive on cbd oil cbd oil that tastes like weed zilis ultracell full spectrum hemp cbd topical vaping cbd oil side effects cbd santa cruz hookah mania gummy bear cartoons escape room melbourne cbd oil memes sublingual melatonin cvs cpt plus cbd pain freeze how long does marijuana stay in your system cbd oil lexapro bakersfield dispensaries does cbd oil increase libido ulcerative colitis treatment cbd free trial ibuprofen 600 mg dosage frequency herban market cbd oil cbc test can you put cbd oil in a juul importing cbd oil from china taking cbd is cbd oil gluten free 750mg cbd oil cbd oil jensen beach thymocytes definition

weight loss surgery cost healthy recipes for weight loss myo inositol weight loss weight loss workout plan women hydroxycut reviews weight loss weight loss diets for diabetes lunch smoothies for weight loss how much weight loss on atkins express weight loss clinic tyler tx maca root for weight loss skin tightening after weight loss kaiser weight loss surgery dandelion for weight loss nutri diet pills weight loss institutes amazing weight loss stories pro ana before and after weight loss betaine hcl weight loss weight loss diet for diabetics two weeks weight loss plan albuterol dosage weight loss best weight loss plan for over 40 rebel wilson weight loss now healthy grocery list for weight loss celexa weight loss or gain fasting weight loss before and after chlorogenic acid weight loss psyllium weight loss weight loss meal prep shopping list acidophilus probiotic weight loss 6 vegetarian recipes for weight loss adipex and alcohol cassie davis weight loss pickled beets weight loss weight loss food plan delivery 30 day weight loss program weight loss skin removal surgery best weight loss muscle gain supplement one xs weight loss pills weight loss success pictures weight loss pills fat burners hypnosis near me for weight loss turbo slim diet pills weight loss best wii workout games for weight loss hydroxycut diet pills side effects isotonix weight loss d master diet pills reviews best it works products for weight loss quick weight loss schemes adele weight loss pill calorie diet calculator weight loss bubba watson weight loss best weight loss diet ever weight loss before pregnancy phentermine drug classification topamax for weight loss xenadrine reviews weight loss pills x shark tank fat loss product 30 day weight loss pills

sexual appetite birth control and sex drive want your sex fully erect how to get over being used sexually male size enhancement drug types chart health store generic sildenafil citrate 20 mg dmp pills viagra or cialis better dick sizes herbal medicine for ed herb names for girls how to make your penis fatter where do you buy viagra how do i make my cock bigger viagra after prostate removal massage table extenders natural erection supplements cock ring results no sex sign what is a good penis length male underwear enhancement sling how to predict penis size sex enhancer medicine naturally boosting testosterone does sex increase penis size men suppliments improve penis girth how to increase sexual endurance vitamin for sexuality male enhancement to last longer viagra free hydromax penis pump is viagra covered under insurance dick in hindi natural sex booster fake viagra best supplement for erection color oops ingredients long hard dick british journal of urology best mens supplement nitric oxide foods supplements why do dicks get hard men hardon medicine for erection stiff nights pill for sale gmc vitamin size of uk steel labido size of panis with photo penis head irritation m 360 pill how do you spell viagra is taking testosterone safe insert dick hydro xtreme guy in amazon box