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Naltrexone modulates growth in infant rats

Naltrexone modulates growth in infant rats
Publication Type
Journal Article
Research Type
Reported as
December 12, 1983
Zagon IS, McLaughlin PJ.
Pennsylvania State University
Naltrexone, a potent opiate antagonist, had both stimulatory and inhibitory effects on somatic growth in preweaning rats depending on dose. Daily injections of 50 mg/kg Naltrexone, which blocked morphine-induced analgesia for 24 hr/day, resulted in increased body and organ weights, and acceleration in the appearance of physical characteristics and maturation of spontaneous motor activity. Naltrexone in a dosage of 1 mg/kg, which blocked morphine-induced analgesia for 4 hr/day, had the opposite effects. These results show that Naltrexone can modulate growth, and suggest a role for the endorphins and opiate receptors in developmental events.

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