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Opioid antagonists inhibit the growth of metastatic murine neuroblastoma

Opioid antagonists inhibit the growth of metastatic murine neuroblastoma
Publication Type
Journal Article
Research Type
Reported as
November 01, 1983
Zagon IS, McLaughlin PJ.
Pennsylvania State University

Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20 Y neuroblastoma (NB) in A/Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69% tumor take, 70% delay in time prior to tumor appearance, and a 60% increase in median survival time. Inoculation of NB in control mice resulted in 100% tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.

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