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Opioid antagonists inhibit the growth of metastatic murine neuroblastoma

Title
Opioid antagonists inhibit the growth of metastatic murine neuroblastoma
Publication Type
Journal Article
Research Type
Animal
Reported as
Date
November 01, 1983
Authors
Zagon IS, McLaughlin PJ.
Institution
Pennsylvania State University
Link
Abstract

Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20 Y neuroblastoma (NB) in A/Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69% tumor take, 70% delay in time prior to tumor appearance, and a 60% increase in median survival time. Inoculation of NB in control mice resulted in 100% tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.