Find us on:

Use of LDN As A Potential Treatment For Multiple Sclerosis

Dr. Maira Gironi
November 01, 2009
Interview with Dr. Maira Gironi, Institute of Experimental Neurology (INSPE) and Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
Looking for a prescriber to consult about LDN?
Find one in your area
What gave you the initial idea that LDN might be effective in multiple sclerosis?

LDN has been thought to trigger prolonged release of beta-endorphins (BE) - endogenous opioids exerting several influences on the immune system. In addition, this opioid has shown to interact at different levels with the endocannabinoid system. This finding drove us to speculate that both the symptomatic effect (i.e. on spasticity) and the cannabinoid-mediated neuroprotection (extensively documented by literature) could be co-shared by BE and by a drug increasing their level, such as LDN.

Could you tell us a little about your clinical work with LDN in multiple sclerosis?

We ran an open-label trial of LDN (4 mg/day) in 40 patients with a diagnosis of primary progressive multiple sclerosis (MS). Five drop-outs occurred and only two major adverse events were reported, the remaining side effects being mild and transitory. Although the study was not powered specifically to assess efficacy, a significant effect on spasticity, and some positive influence on fatigue and depression were observed. However the most striking result was the beta-endorphin increase, which began 3 months after the start of therapy and was still evident one month after therapy discontinuation. This confirmed that the drug is at least biological active.

How have you found patient satisfaction with LDN compared with other therapies?

The subjective satisfaction of patients wasn't specifically investigated, but the rate of response to some of the symptoms evaluated (i.e. spasticity, fatigue, depression and some items of quality of life) suggest a high level of satisfaction.

Is patient compliance with LDN better than with other therapies?

Considering the rate of drop-outs (12 percent), we believe that this drug could be well tolerated.

What side effects have your patients encountered?

Most side effects documented were mild and reversible (i.e. a moderate increase in spasticity, urinary infections or mild liver enzymes increase). Very few were severe such as hepatic steatosis , or worsening disease.

What are the main benefits of using LDN compared with other standard therapies for multiple sclerosis?

The cost/effectiveness ratio is strongly in favour of LDN. On the negative side, LDN causes mild and transient adverse effects; on the positive side, it offers the convenience of oral administration, with low cost, good compliance and some effect on spasticity.

Do you believe LDN should be used widely in all patients with multiple sclerosis?

In order to address this question we are designing a second study aimed at investigating the objective effectiveness of the drug. A randomized, controlled, double-blind trial will clarify whether or not the effects reported are just placebo-triggered. We believe this hypothesis is unlikely because of the objective increase detected in BE.

male enhancement: improving sex drive nitrate and viagra husband no sex drive penile dysfunction drug reviews the best male enlargement pills nizagara review over the counter erection blue sex pills ed pumps best penis messages male enhancement kenya how to increse penis size vitamin that help blood flow i need penis goat pills what is the size of an average penis maximum pills natural pills gas station ed pills austin powers pump revatio 20 mg vs viagra cant keep erection long dick pills obesity is defined as quizlet amazon sex alpha male testosterone viagra and alcohol penes infection pictures what is sexual stimulation nearest health store cialis pills online adams secret male enhancement vacuum dick male enhancement vitalikor viagra usage

cbd oil: cbd oil legal in georgia heavy metal poisoning from cbd oil cbd tendonitis sun cbd oil cbd oklahoma city uses for hemp oil cbd approved by fda cbd vape oil 500mg cbd oil indiana law cbd joint balm cbd free shipping code 2016 edibles meme cbd hemp direct reddit plumblink cape town cbd cbd oil vape review cbd clinical trials cbd power menopause and cbd oil what does smoking cbd oil do cbd oil elixinol cbd oil in ear for tinnitus cbd oil how often to take hemp oil uses cbd oil reviews for inflammation epidiolex availability caffeine withdrawal cannabis oil for rheumatoid arthritis garden of life cbd reviews me hair removal reviews cbd vape anxiety rk tongue co inc cbd oil and lyrica cbd america buy hemp cbd hemp cbd oil store near me cbd xanax interaction

weight loss: anxiety and weight loss what is the quick weight loss program prescription weight loss medications online weight loss clinic ann wilson weight loss overnight weight loss detox juice recipes for weight loss levothyroxine and diet pills weight loss breakfast menu dietitian for weight loss metformin hcl 1000 mg weight loss what weight loss pills work fast weight loss infographic weight loss military diet weight gain after weight loss surgery super extreme diet pills diindolylmethane weight loss horizon weight loss pills chastity bono weight loss celebrities who had weight loss surgery weight loss vlog treadmill speed for weight loss weight loss virtual model best diet pills for diabetes type 2 weight loss pills benefits juice diet 30 days weight loss weight loss pills hormones organic diet pills cut back diet pills no carb diet weight loss expectations p57 hoodia diet pills young living oil for weight loss diets diet pills 14 year old weight loss is adipex a controlled substance quick weight loss tips for obese

vape: element vape coupon code reddit 2019 vape thc with e cigarette vape store locator vape shop north myrtle beach get weird vape voopoo drag custom display unny vapor range smok t10 coils ecig lounge kangertech subox tank ecig bottle best juice to refill juul humble coupon ecig empire rba rebuild e cigarette store medford oregon vitamin vape juice e cigarette wated creen was local vape vaping instead of smoking optimum temp for voopoo vape coil for smok alien vape wire and cotton vape snow wolf 200w how to find flavors of ecig vapor seller legit pegasus aspire mod firmware update for smok e xname v12 ecigarettes explode uwell crown clone trouble evod vape pen amazon uwell crown blakcv reddit best vape cheap black and green voopoo drag electronic cigarette mod parts ecig voopoo drag reload sigelei kaos firmware