Find us on:

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.


Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

people who have sex with dead people best way to increase testosterone online viagra where to buy asox9 erection medication sex position clips romans com coupons buy ed pills online dick inches ww pandora dick plastic surgery best organic supplements is my cock big enough cheap viagra 100mg herbal male enhancement closest supplement to steroids average dick pictures pumper dick best foods to boost testosterone how to get a bigger penis at home noxitril amazon pills for a bigger pennis does ageless male tonight work best foods to build testosterone black ant pills side effects penis enlargment system nitroxin male enhancement no chest no sex dick implants pumper dick viagra 4 hour warning you make my dick hard viagra results before and after male enhancement free trial otc online guys with fat dicks help maintain erection what does a sexual means high blood pressure supplements whats the average penis length extend for men penis pump risks grow room kit enhancement male underwear androzene free trial uncircumcised dicks pics gnc vitamin store near me tadacip 20 rash on penis after sex how to get a longer dick the smallest penis in the world buspar erectile dysfunction alpha jym gnc aspirin and viagra p6 pm reviews male enhancement health risks effects of testosterone shots blue pill men harder erections tree bark repair methods

cbd balm best cbd cream for arthritis how much is cbd oil karaoke bar melbourne cbd best cbd cartridges intoxicate meaning cbd 101 green rose cbd oil how often can you take cbd oil how to use cbd oil for cooking cbd oil alaska cannabis cbd effects zilis cbd hemp oil reviews cbd oil at tradeshows is full spectrum cbd legal i doser marijuanaqh effect pcos and marijuana the cbd green gold cbd wise oil group is cbd oil legal in fl cbd pre workout how to measure cbd isolate amazon hemp oil choosing the right cbd oil cbd oil sunfower lecithen cbd effect on liver whats the difference between hemp extract and cbd oil blueberry cbd oil does cbd oil help with alzheimers cbd flower sacramento results fitness reviews cbd vape oil effects best cbd vape for anxiety spectrum def is cbd oil a miracle for multiple sclerosis meaning of relieved cbd full spectrum benefits bull city vapor coupon 2017 will i test positive for marijuana if i use cbd oil advantage multi cbd and leaky gut best cannabis for back pain cbd vape for pain wikipedia paris attack marys medicinals cbd best hemp oil cannabear dc cbd oil murray utah vaporizing cbd oil cbd oil twin falls green remedy cbd oil reviews cbd vape oil mg ethanol free gas near me can i buy cbd oil and take it home gw pharmaceuticals cbd oil conference cbd global extracts does cbd oil increased depression joe manganiello

creatine weight loss decaffeinated green tea weight loss what is dead weight loss qigong exercises for weight loss doctor rogers weight loss gastroparesis weight loss mark harmon weight loss perfect slim diet pills review weight loss houston micro diet weight loss dr oz weight loss programme loose skin from weight loss natalie portman black swan weight loss are nectarines good for weight loss tejocote weight loss victoza weight loss side effects weight loss institutes medi weight loss billerica thc weight loss b12 shots weight loss top probiotics for weight loss buy weight loss pills online jon stewart weight loss swedish weight loss services weight loss during puberty dr oz recommended weight loss pills best weight loss programs 2017 supernatural weight loss prayer does l glutamine help with weight loss ab slim diet pills mens before and after weight loss weight loss diets and exercise plans motivational weight loss videos ebay diet pills weight loss replacement shakes kelly ripa weight loss intense workout plan for weight loss crossfit weight loss program adele weight loss 2016 does water help weight loss hgc hormone weight loss best weight loss for women over 50 good diet pills for fast weight loss cincy weight loss weight loss pills gnc reviews dextrin diet pills weight loss pills in black bottle can zoloft cause weight loss most effective weight loss pills at gnc no diet pills adipex diet pills for sale best diet pills that give you energy diet pills chattanooga tn rowing for weight loss best supplements for quick weight loss watermelon juice recipe for weight loss smoothies for quick weight loss keto weight loss pills side effects keto boost from shark tank wausau weight loss clinic reviews

vape no A Tag